Toward and beyond lysosomes.
نویسنده
چکیده
منابع مشابه
BORC coordinates encounter and fusion of lysosomes with autophagosomes
Whereas the mechanisms involved in autophagosome formation have been extensively studied for the past 2 decades, those responsible for autophagosome-lysosome fusion have only recently begun to garner attention. In this study, we report that the multisubunit BORC complex, previously implicated in kinesin-dependent movement of lysosomes toward the cell periphery, is required for efficient autopha...
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Lysosome mobilization is a key cellular process in phagocytes for bactericidal activities and trans-matrix migration. The molecular mechanisms that regulate lysosome mobilization are still poorly known. Lysosomes are hard to track as they move toward phagosomes throughout the cell volume. In order to anticipate cell regions where lysosomes are recruited to, human and RAW264.7 macrophages were s...
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The sorting of macromolecules within and between membranous organelles is often directed by information contained in protein primary or secondary structure. We show here that absent such structural information, macromolecules internalized by endocytosis in macrophages can be sorted by size. After endocytosis, small solute probes of fluid-phase pinocytosis were recycled to the extracellular medi...
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Background: Insulin downregulates GLUT4 by accelerating degradation in lysosomes. Results: Insulin through H2O2 production dissociates retromer from LDM membrane in a protein kinase CK2-dependent manner. Conclusion: Insulin switches GLUT4 traffic route toward lysosomes via retromer inhibition. Significance: This revealed a unique oxidative stress-mediated insulin signal cascade that regulates t...
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Perfluorinated compounds (PFCs) such as perfluorooctanesulfonate (PFOS) are stable chemicals that accumulate in biological matrix. Toxicity of these compounds including immunotoxicity has been demonstrated in experimental models and wildlife. Although limited number of studies examined the effects of PFOS on human lymphocytes but so far no research has investigated the complete mechanisms of PF...
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عنوان ژورنال:
- Cell structure and function
دوره 27 6 شماره
صفحات -
تاریخ انتشار 2002